European DOHaD Conference

Oral presentation

Maternal supplementation with chia seeds-derived alpha-linolenic acid enhances n-3 LCPUFA levels and attenuates anxiety and hyperactivity in the offspring of obese rats.

Garance Dalix^a, Maeve Delacroix^a, Alexis Gandon^a, Anne-Lyse Panheleux^a, Blandine Castellano^a, Clair-Yves Boquien^a, Vincent Paillé^a, Véronique Ferchaud-Roucher^a

a. Nantes Université, CHU Nantes, INRAE UMR 1280 PhAN, F-44000 Nantes, France. 

Posters

Neurotoxic tryptophan profile in the placenta and umbilical cord in children with critical congenital heart disease.

Alban-Elouen Baruteau^abc, Marie Soulard^ab, Marie Demonceaux^a, Mathilde Gourdel^d, Bénédicte Romefort^b, Garance Devarenne^ae, Norbert Winer^ae, Véronique Ferchaud-Roucher^a

a. Nantes Université, CHU Nantes, INRAE UMR 1280 PhAN, F-44000 Nantes, France  
b. Nantes Université, CHU Nantes, Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, CIC FEA 1413, F-44000 Nantes, France 
c. Nantes Université, CNRS, INSERM UMR 1087 l’institut du thorax, F-44000 Nantes, France 
d. Nantes Université, Mshark, Biocore, F-44000 Nantes, France 
e. Nantes Université, CHU Nantes, Department of Obstetric and Gynecology, F-44000 Nantes, France

Maternal age as a trigger of perinatal programming of the immuno-microbial trajectory.

Eva Guilloteau¹, Aurélie Durand¹, Blandine Castellano¹, Alexis Gandon¹, Amandine Lefebvre¹, Sandrine Suzanne¹, Kenza Mourji², Delphine Cussigh², Benoit Chassaing², Véronique Ferchaud-Roucher¹, Emelyne Lécuyer¹

1. INRAE, Nantes Université, UMR 1280, Physiopathology of Nutritional Adaptations, Nantes, France
2. Mucosal Microbiota in Chronic Inflammatory Diseases, INSERM U1016, CNRS UMR 8104, Université de Paris, Paris, France

Female offspring exposed in utero to hyperglycaemia presented specific insulin sensitivity pathways at adulthood depending on breast milk metabotype received: evidence from a rodent model.

Bobin Paul¹, Perumal Hariprasath¹, Pierre De Coppet¹, Castellano Blandine¹, Panheleux Anne-Lyse¹, Grit Isabelle¹, Cloteau Chloé^2,3, Le Dréan Gwenola¹, Alexandre-Gouabau Marie-Cécile¹

1. Nantes Université, INRAE, UMR 1280, PhAN, CRNH-OUEST, IMAD, F-44000 Nantes, France.
2. Nantes Université, CNRS, INSERM, L'institut du Thorax, Nantes, France
3. Nantes Université, CHU Nantes, Inserm, CNRS, SFR Santé

The effect milk composition in gestational diabetes mellitus on the incretin function of offspring in rats, and in vitro screening of milk biomarkers in enteroendocrine cell line.

Bobin Paul¹, Santos Hernandez Marta², Christopher Smith², De Coppet Pierre¹, Hulin Philippe³, Castellano Blandine¹, Grit Isabelle¹, Gribble Fiona², Reimann Frank², Alexandre-Gouabau Marie-Cécile¹, Le Dréan Gwenola¹.

1. Nantes Université, INRAE, UMR 1280, PhAN, CRNH-OUEST, IMAD, F-44000 Nantes, France.
2. Institute of Metabolic Science and MRC Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
3. Nantes Université, CHU Nantes, CNRS, Inserm, BioCore, US16, SFR Bonamy, F-44000 Nantes, France

Stimulation of lactation in pregnant rats through dietary arginine supplementation.

Francisca Ngenda Kabombo^1,2, Antoine Gautier¹, Madia Charlier³, Angela Tesse⁴, Isabelle Grit¹, Blandine Castellano¹, Pierre De Coppet¹, Yvan Choiset¹, Paul Mobinzo Kapay², Khadija Ouguerram¹, Clair-Yves Boquien¹

1. Nantes Université, INRAE, UMR 1280, PhAN, IMAD, CRNH-Ouest, F-44000, Nantes, France
2. Université Nouveaux Horizons, Faculté des Sciences des Aliments et de l'Environnement, Lubumbashi, République du Congo
3. Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France
4. Nantes Université, INSERM, TENS, IMAD, F-44000, Nantes, France

The inability of the early microbiota to produce indole-3-lactic alters ileal enteroendocrine cells function in mice.

Armand Dufeil¹, Maëva Rebion¹, Elise Miller², Yvan Choiset¹, Odile Tresse¹, Patricia Parnet¹, Laurent Naudon³, Sylvie Rabot², Catherine Michel¹, Vincent Paillé¹, Gwenola Le Dréan¹

1. Nantes Université, INRAE, UMR 1280, PhAN, IMAD, F-44000 Nantes, France
2. Université Paris-Saclay, INRAE, AgroParisTech, Institut Micalis, Jouy-en-Josas, France
3. Université Paris-Saclay, INRAE, AgroParisTech, CNRS, Institut Micalis, Jouy-en-Josas, France