The HAL open archive is intended for accessing the scientific work of UMR 1280 PhAN:
https://hal.inrae.fr/PHAN
Publications 2026:
*Evaluation of chromatin accessibility in cultured fetal hypothalamic neuroprogenitors following maternal protein restriction in rats.
Amarger, V., Frapin, M., & Vancamp, P. (2026). Cells & Development, 187, 204100.
https://doi.org/10.1016/j.cdev.2026.204100
*Maternal diet enrichment in n-3 long-chain polyunsaturated fatty acids during pregnancy and lactation improves their transfer from the mother to the offspring and counterbalances high-fat diet-induced alterations in a sex-dependent manner in rats.
Moullé, V. S., David-Sochard, A., Castellano, B., Grit, I., Gandon, A., Martin, J.-C., & Parnet, P. (2026). Current Developments in Nutrition, 109508.
https://doi.org/10.1016/j.cdnut.2026.109508
*Increased intake of foods providing alpha-linolenic acid modifies nutritional and non-nutritional characteristics of breast milk: a randomized clinical trial.
Thibault, R., Boudry, G., Legrand, P., Boquien, C. Y., Mairesse, G., Catheline, D., Kerhoas, N., Guillevic, M., Rousseau, C., Laîné, F., Blat, S., Le Huërou-Luron, I., Le Gall, S., Thoulouze, L., Alexandre-Gouabau, M. C., Laviolle, B., Goujon, J. M., Poffo, L., Le Page, R., Schmitt, B. (2026). Journal of Nutrition, 101787.
https://doi.org/10.1016/j.tjnut.2026.101787
*Beyond protective factors and normal IQ in preterm children: More executive disorders than expected.
Cadeau, O., Muller, J., Guerra, A., Boscher, C., Frondas, A., Rozé, J., Flamant, C., Boquien, C., Simon, L., & Roy, A. (2026). Journal of Neuropsychology.
https://doi.org/10.1111/jnp.70065
*Paternal DHA supplementation before conception shapes offspring lipid metabolism in a sex- and postnatal diet-dependent manner.
Quynh, D. D., García-Santillán, J. A., Van ThuanVăn, N., & Bolaños-Jiménez, F. (2026). Nutrition Research.
https://doi.org/10.1016/j.nutres.2026.08.003
* Adaptive response of breastmilk metabotype and miRNA patterns in a rat model of gestational diabetes and its postpartum evolution.
Bobin P, Le Guillou S, David-Sochard A, Gandon A, Gourdel M, Cloteau C, Moyon T, Charlier M, Darmaun D, Le Dréan G, Alexandre-Gouabau MC. J Nutritional Biochemistry, 2026, JNB-D-25-01729R3, just accepted
* Antenatal N-acetylcysteine supplementation in pregnant women with impending preterm birth.
Küster A, Legrand A, Vibet MA, Nguyen PC, Winer N, Barribaud M, Gourdel M, Boivin M, Vincke M, Flet L, Darmaun D, Alexandre-Gouabau MC, Pediatric Research, 2026, PR-2025-2011.R1, just accepted
* Chia Seed Enrichment In High-Fat-High-Sugar Diet-Induced Obesity: A Strategy to Increase DHA Levels In Maternal Tissues And In Fetal Placenta And Brain During Pregnancy
Garance Dalix, Chloé Cloteau, Khadija Ouguerram, Blandine Castellano, Anne-Lyse Panheleux,
Isabelle Grit, Norbert Winer, Clair-Yves Boquien, Véronique Ferchaud-Roucher PMID: 42134024, DOI: 10.1016/j.plefa.2026.102746
*Eczema in inborn errors of immunity with atopy: frequency, timing, phenotypic clustering.
Aubert, H., Mahlaoui, N., Barbarot, S., Alligon, M., Pellier, I., Mallebranche, C., Bustamante, J., Rosain, J., Picard, C., Néel, A., Bodinier, M., Brosseau, C., Polivka, L., Bodemer, C., & Thomas, C. (2026). British Journal of Dermatology.
https://doi.org/10.1093/bjd/ljag308
Publications 2025 :
* Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate.
Guendel F, Lécuyer E. Eur J Immunol. 2025 Nov;55(11):e70088. doi: 10.1002/eji.70088. PMID: 41195866.
* Sex-specific differences in the influence of maternal obesity on the oxidative and inflammatory status in the maternal-placental-fetal unit : new insights ninto the placental sphingolipid profile.
Marta Hita Hernández, Esther Dos Santos, Yoann Rodriguez, Veronique Ferchaud-Roucher, Delphine Rousseau-Ralliard, Anne Frambourg, Paul Berveiller, François Vialard, Anne Couturier-Tarrade, Marie-Noëlle Dieudonné. Mol Cell Endocrinol. 2025 Oct 1:608:112640. doi: 10.1016/j.mce.2025.112640
* An update on current methods for studying microbiome-host interactions in health and diseases
Naour, M., Ezzine, C., Michel, C., Mathieu, E., Lejard, V., Le Dréan, G., Lelièvre, J.M., Lapaque, N., Doré, J. and Blottière, H.M. Animal - Science Proceedings 16 (2025) 299–421
* Reduced availability of essential amino acids disrupts differentiation of anorexigenic POMC neurons in the fetal rat hypothalamus.
Pieter Vancamp, Isabelle Grit I, Marie Demonceaux, Veronique Ferchaud-Roucher, Patricia Parnet*, Valérie Amarger*. Mol Neurobiol. 2025 Jul 18. doi: 10.1007/s12035-025-05201-z.
* Correction: Associations Among Diet, Health, Lifestyle, and Gut Microbiota Composition in the General French Population: Protocol for the Le French Gut - Le Microbiote Français Study.
Connan C, Fromentin S, Benallaoua M, Alvarez AS, Pons N, Quinquis B, Morabito C, Nazare JA, Borezée-Durant E; Le French Gut Consortium; Haimet F, Ehrlich SD, Valeille K, Cavezza A, Blottière H, Veiga P, Almeida M, Doré J, Benamouzig R.
JMIR Res Protoc. 2025 Jul 14;14:e80127. doi: 10.2196/80127.
PMID: 40658453
* A specific metabolomic and lipidomic signature reveals the post-partum resolution of gestational diabetes mellitus or its evolution to Type 2 Diabetes in rat.
Paul Bobin, Mitanchez D, Castellano B, Grit I, Moyon T, Raux A, Vambergue A, Winer N, Darmaun D, Michel C, Le Drean G, Alexandre-Gouabau MC. American Journal of Physiology-Endocrinology and Metabolism 2025 ; doi :10.1152/ajpendo.00396.2024
* Impact of Lipid Oxidation Products on Inflammation and Insulin Resistance: A Focus on Mechanisms of Action.
Hajri T, Ouguerram K, Fungwe TV. Cell Biochem Biophys. 2025 Jul 1. doi: 10.1007/s12013-025-01812-4. Online ahead of print. PMID: 40591136
* Associations Among Diet, Health, Lifestyle, and Gut Microbiota Composition in the General French Population: Protocol for the Le French Gut - Le Microbiote Français Study.
Connan C, Fromentin S, Benallaoua M, Alvarez AS, Pons N, Quinquis B, Morabito C, Nazare JA, Borezée-Durant E; Le French Gut Consortium; Haimet F, Ehrlich SD, Valeille K, Cavezza A, Blottière H, Veiga P, Almeida M, Doré J, Benamouzig R.
JMIR Res Protoc. 2025 May 13;14:e64894. doi: 10.2196/64894.
PMID: 40358997
* MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts.
Lefebvre CC, Giowachini P, Derrien J, Naour M, Corre I, Thirouard L, Douillard E, Chiron D, Guillonneau F, Treps L, Campone M, Juin PP, Souazé F.
Cell Death Dis. 2025 Aug 9;16(1):603. doi: 10.1038/s41419-025-07920-6.
PMID: 40783386 Free PMC article.
* Congenital heart diseases and neurodevelopmental disorders: new insights through the DOHaD hypothesis.
Marie Demonceaux, Oscar Werner, Amanda Guerra, Olivier Cadeau, Arnaud Roy, Veronique Ferchaud-Roucher*, Alban-Elouen Baruteau, JACC Basic Transl Sci. 2025 Aug ;10(8) :101251. doi: 10.1016/j.jacbts.2025.01.022.
* A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research.
Metwaly A, Kriaa A, Hassani Z, Carraturo F, Druart C; IHMCSA Consortium; Arnauts K, Wilmes P, Walter J, Rosshart S, Desai MS, Dore J, Fasano A, Blottiere HM, Maguin E, Haller D.
Nat Rev Gastroenterol Hepatol. 2025 May;22(5):343-356. doi: 10.1038/s41575-025-01041-3. Epub 2025 Mar 3.
PMID: 40033063 Review.
* Cholecystokinin modulates corticostriatal transmission and plasticity in rodents.
Guillaume C, Sáez M, Parnet P, Reig R, Paillé V (2025) eNeuro ENEURO.0251-24.2025.
* Boosting Fertility Through Tryptophan: Linking Diet, Hormones, and the Gut Microbiome.
Paillé V (2025), J Nutr S0022-3166(25)00361-X.
* Diet-Induced Obesity in the Rat Impairs Sphingolipid Metabolism in the Brain and This Metabolic Dysfunction Is Transmitted to the Offspring via Both the Maternal and the Paternal Lineage
Santilla JAG, Mezo-González CE, Gourdel M, Croyal M, Bolaños-Jiménez F. .J Neurochem. 2025. Jan ;169(1): e16307. doi: 10.1111/jnc.16307. PMID : 39831759.
* Maternal low protein diet alters the development of reward circuits from childhood to adulthood by reshaping its function.
Paradis J, Guillaume C, Frapin M, Meistermann D, Pagniez A, de Coppet P, Amarger V, Parnet P, Paille V (2025) (biorxiv) https://www.biorxiv.org/content/10.1101/2025.02.28.639479v1
* Associations of Maternal Diet with Nutritional and Chemical Exposure Markers in Human Milk from the LACTACOL Cohort of Preterm Infants. European Journal of Nutrition
Boquien CY, Moyon T, Billard H, David-Sochard A, Boscher C, Simon L, Roze JC, De Lauzon-Guillain B, Antignac JP, Mahieu B, Alexandre-Gouabau MC, Vigneau E, Cano-Sancho G. 2025 ; doi : 10.1007/s00394-025-03658-1
* Microbiote néonatal et comportement alimentaire chez l'adulte
Patricia Parnet, Gwenola Le Dréan, Maxime Naour, Isabelle Grit, Christine Heberden, Emmanuelle Le Chatelier, Catherine Michel, Cahiers de Nutrition et de Diététique, 2025, ISSN 0007-9960, https://doi.org/10.1016/j.cnd.2025.07.005.
Publication 2024 :
* Synthesis of phospholipids in human placenta.
Theresa L Powell, Veronique Ferchaud-Roucher, Lana Madi, Chris Uhlson, Karin Zemski-Berry, Avery C Palmer, Katheryn Erickson, Stephanie S Chassen, Marisol Castillo-Castrejon.
hal-04661240v1
* The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation.
Le Dréan ME, Le Berre-Scoul C, Paillé V, Caillaud M, Oullier T, Gonzales J, Hulin P, Neunlist M, Talon S, Boudin H
hal-04666939v1
* Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating.
M, de Araujo A, Singh A, Yang M, Braga I, Paille V, Mendez-Hernandez R, Vergara M, Woodie LN, Gour A, Sharma A, Urs N, Warren B, de Lartigue G
hal-04634266v1
* Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications.
Pieter Vancamp, Morgane Frapin, Patricia Parnet, Valérie Amarger.
hal-04665894v2
* Unraveling the benefits of Bacillus subtilis DSM 29784 poultry probiotic through its secreted metabolites: an in vitro approach.
Vieco-Saiz N, Prévéraud DP, Pinloche E, Morat A, Govindin P, Blottière HM, Matthieu E, Devillard E, Consuegra J.
DOI: 10.1128/spectrum.00177-24
* Preventive effects of a nutraceutical mixture of berberine, citrus and apple extracts on metabolic disturbances in Zucker fatty rats.
Siliman Misha M, Destrumelle S, Le Jan D, Mansour NM, Fizanne L, Ouguerram K, Desfontis JC
hal-04815231v1
* Adult rats sired by obese fathers present learning deficits associated with epigenetic and neurochemical alterations linked to impaired brain glutamatergic signaling.
Carla Elena Mezo‐gonzález, Juan Antonio García‐santillán, Bertrand Kaeffer, Mathilde Gourdel, Mikaël Croyal, Francisco Bolaños‐jiménez.
hal-04402176v1
* New alternatives to holder pasteurization in processing donor milk in human milk banks
Guido E Moro, Melissa Girard, Chiara Peila, Nadia Garcia, Diana Escuder-Vieco, Kristin Keller, Tanya Cassidy, Enrico Bertino, Clair-Yves Boquien, Rachel Buffin et al.
hal-04644392v1
* Glutamate from the microbiome controls host metabolism.
Le Dréan G, Blottière HM.
hal-04660656v1
* New alternatives to holder pasteurization in processing donor milk in human milk banks
Guido E Moro, Melissa Girard, Chiara Peila, Nadia Garcia, Diana Escuder-Vieco, Kristin Keller, Tanya Cassidy, Enrico Bertino, Clair-Yves Boquien, Rachel Buffin et al.
hal-04644392v1
* Vegan/vegetarian diet and human milk donation : An EMBA survey across European milk banks
Serena Gandino, Agnieszka Bzikowska‐jura, Karolina Karcz, Tanya Cassidy, Aleksandra Wesolowska, Barbara Królak‐olejnik, Daniel Klotz, Sertac Arslanoglu, Jean-Charles Picaud, Clair‐yves Boquien et al. DOI: 10.1111/mcn.13564
* Gestational cholestyramine treatment protects adult offspring of ApoE-deficient mice against maternal-hypercholesterolemia-induced atherosclerosis.
Habib M, Croyal M, Kaeffer B, Grit I, Castellano B, Gourdel M, Le May C, Thorin C, Nazih H, Ouguerram K.
hal-04797680v1
